Pulmonary and Cardiorenal Cyclooxygenase-1 (COX-1), -2 (COX-2), and Microsomal Prostaglandin E Synthase-1 (mPGES-1) and -2 (mPGES-2) Expression in a Hypertension Model
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چکیده
منابع مشابه
Pulmonary and Cardiorenal Cyclooxygenase-1 (COX-1), -2 (COX-2), and Microsomal Prostaglandin E Synthase-1 (mPGES-1) and -2 (mPGES-2) Expression in a Hypertension Model
Hypertensive mice that express the human renin and angiotensinogen genes are used as a model for human hypertension because they develop hypertension secondary to increased renin-angiotensin system activity. Our study investigated the cellular localization and distribution of COX-1, COX-2, mPGES-1, and mPGES-2 in organ tissues from a mouse model of human hypertension. Male (n = 15) and female (...
متن کاملUpregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results.
BACKGROUND AND PURPOSE Cyclooxygenase-2 (COX-2) and Microsomal Prostaglandin E2 Synthase-1 (mPGES-1) catalyze isomerization of the cyclooxygenase product PGH2 into PGE2. Deletion of COX-2/mPGES-1 suppresses carotid artery atherogenesis and angiotensin II-induced aortic aneurysms formation, and attenuates neointimal hyperplasia after vascular injury in mice. The upregulation of COX-2/mPGES-1 in ...
متن کاملRole of COX-2/mPGES-1/Prostaglandin E2 Cascade in Kidney Injury
COX-2/mPGES-1/PGE2 cascade plays critical roles in modulating many physiological and pathological actions in different organs. In the kidney, this cascade is of high importance in regulating fluid metabolism, blood pressure, and renal hemodynamics. Under some disease conditions, this cascade displays various actions in response to the different pathological insults. In the present review, the r...
متن کاملAltered expression of COX-1, COX-2, and mPGES in rats with nephrogenic and central diabetes insipidus.
Prostaglandins have an important role in renal salt and water reabsorption. PGE2 is the main kidney prostaglandin and is thought to be mainly produced in the kidney inner medulla (IM). There are indications that PGE2 synthesis in nephrogenic (NDI) and central (CDI) diabetes insipidus is altered. We hypothesize that the expression of the major PGE2 synthesis enzymes cyclooxygenases 1 and 2 (COX-...
متن کامل2. Cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in the pathophysiology of osteoarthritis
The exact etiology of osteoarthritis (OA) is not fully understood and as a result no appropriate curative therapeutics are currently available to halt the progression of this disease. Mediators derived from the arachidonic acid (AA) metabolic pathway, especially prostaglandins (PGs), are believed to play a crucial role in the pathophysiology of this disease. Among the various PGs, PGE2 is the m...
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ژورنال
عنوان ژورنال: Mediators of Inflammation
سال: 2007
ISSN: 0962-9351,1466-1861
DOI: 10.1155/2007/85091